What to do about it?
If the mailing contains suggestions for removing your name from a mailing list, 10s to 100s of people will respond to the list with "remove" messages meant for the originator. So, the original message (spam) creates more unwanted mail (spam spam spam spam), which generates more unwanted mail (spam spam spam spam spam spam and spam).
For example, I received spam from several senders at aol.com, for example, lookyhere@aol.com. I forwarded the offending messages to abuse@aol.com. If e-mail to an "Abuse" mailbox bounces (doesn't go through) you could try sending it to the sysop, e.g. sysop@xyznet.com.
Happy (spam free) surfing!